Isaac married Elizabeth Gardner in 1791. Elizabeth (daughter of Thomas Gardner, Jun. and Anna Worth) was born on 03 Jun 1763; died on 25 Aug 1826 in Ohio. [Group Sheet] [Family Chart]

1. Mary Sisson was born on 07 May 1793.
2. Eunice Sisson was born on 30 Mar 1795; died on 08 Jul 1880.
3. Anna Sisson was born on 08 Nov 1798; died on 12 Jan 1853 in Cincinnati, Ohio.